Statins are used in a wide range of applications. They are cholesterol-lowering and anti-atherosclerotic drugs. For patients with atherosclerotic cardiovascular disease, patients over 40 years of age with diabetes, those with a low serum lipoprotein cholesterol of more than 4.9 mmol per liter, and patients with moderate to advanced cardiovascular disease over the next 10 years should be started immediately treatment.
Many patients have concerns about the use of statins. Do you think statins have any side effects? Can not be used on the withdrawal? Now for everyone to answer questions.
There are four main side effects of statins
The first is a statin-induced liver injury, an increase of liver enzymes. The usual clinical measure of the standard is that if the liver enzyme is increased more than 3-fold, statins need to be stopped or reduced.
The second is muscle reaction muscle damage, including myositis muscle weakness. If you have these symptoms, combined with creatine kinase continuous increase, we must guard against. Also need to exclude other factors that can cause elevated kinase, such as strenuous exercise, exercise, muscle strain and so on.
Third, statins cause elevated blood sugar levels. A few years after taking statins may cause mild increases in blood sugar levels. What needs to be considered is whether the benefit of using statins is greater than the increase of blood sugar. Clinical trials prove it does more good than harm. Whether you have diabetes or not, the risk of reducing cardiovascular events after applying statins is far below the risk of elevated blood sugar.
The fourth is the problem of cognition. Some small reactions such as gastrointestinal reactions, emotional changes, insomnia, constipation, they are transient, we can in the application process, comprehensive consideration.
Statin is not only a lipid-lowering drug, but also an anti-atherosclerotic drug. The purpose of using statins not only lipid-lowering, but also prevention. Because high blood lipids bring atherosclerosis, this process, once opened, is accompanied by a lifetime, and even lead to cardiovascular and kidney lesions have consequences, is to prevent such a process.
Long-term use of statins in patients with strong indications who have been shown to have atherosclerosis is beneficial for anti-atherosclerotic effects. For patients who need long-term statin, once disabled, there may be rebound lipids. Atherosclerosis, like hypertension, is a disease that requires long-term management.
Therefore, we should correctly understand the application of statins.